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Article

Markers for dysplasia of the upper aerodigestive tract. Suprabasal expression of PCNA, p53, and CK19 in alcohol-fixed, embedded tissue.

The American journal of pathology - 1 Oct 1992

Coltrera M D, Zarbo R J, Sakr W A, Gown A M

Abstract excerpt

Recognition of premalignant lesions in the oral epithelium has the potential to increase survival rates for squamous cell carcinoma of the oral cavity. It has previously been reported that cytokeratin 19 (CK19), a 40-kd epithelial cytoskeletal protein within the suprabasal squamous epithelium, is a specific marker of moderate-to-severe dysplasia and carcinoma in situ in oral cavity squamous epithelium. In...

Topics

Antigens, Neoplasm
Carcinoma, Squamous Cell
Genes, p53
Humans
Hyperplasia
Immunohistochemistry
Keratins
Mouth
Mouth Mucosa
Mouth Neoplasms
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nuclear Proteins

Pharynx

Precancerous Conditions

Proliferating Cell Nuclear Antigen

Tissue Fixation

Source

Open in PubMed Open full text

Identifiers

PMID: 1384338
PMCID: PMC1886630

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1384338-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Markers for dysplasia of the upper aerodigestive tract. Suprabasal expression of PCNA, p53, and CK19 in alcohol-fixed, embedded tissue.PMID 1384338Read ↗

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