Interleukin-7 is a growth factor for Sézary lymphoma cells.

doi:10.1172/JCI115920

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Interleukin-7 is a growth factor for Sézary lymphoma cells.

The Journal of clinical investigation - 1 Sept 1992

Dalloul A, Laroche L, Bagot M, Mossalayi M D, Fourcade C, Thacker D J, Hogge D E, Merle-Béral H, Debré P, Schmitt C

Abstract excerpt

Sézary syndrome is a cutaneous T cell lymphoma characterized by infiltration of the skin by CD4+ cells. These cells generally respond poorly to mitogens and T cell activators. We have studied the action of IL1 to IL4, IL6, and IL7 on the proliferation of Sézary cells from 12 patients. With the ex...

Topics

Adult
Aged
Antigens, CD
Antigens, CD7
Antigens, Differentiation, T-Lymphocyte
CD4 Antigens
Female
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Humans
Interleukin-2
Interleukin-7
Lymphocyte Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Phenotype

Sezary Syndrome

Skin Neoplasms

Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 1381718
DOI: 10.1172/JCI115920
PMCID: PMC329964

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1381718-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interleukin-7 is a growth factor for Sézary lymphoma cells.PMID 1381718Read ↗

The pleiotropic effects of interleukin 7 and their pathologic and therapeutic implications.Semantic proximity Read ↗

Xenograft and cell culture models of Sézary syndrome reveal cell of origin diversity and subclonal heterogeneitySemantic proximity Read ↗

A clonal CD4-positive T-cell line established from the blood of a patient with Sézary syndrome.Semantic proximity Read ↗

Functional coexpression of Interleukin (IL)‐7 and its receptor (IL‐7R) on Hodgkin and Reed‐Sternberg cells: Involvement of IL‐7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphomaSemantic proximity Read ↗

The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis.Semantic proximity Read ↗

Genotypic, phenotypic and functional analysis of CD4+CD7+ and CD4+CD7- T lymphocyte subsets in Sézary syndrome.Semantic proximity Read ↗

Genetic Manipulation of Tumor-specific Cytotoxic T Lymphocytes to Restore Responsiveness to IL-7Semantic proximity Read ↗

CD4+CD7− T cells compose the dominant T-cell clone in the peripheral blood of patients with Sézary syndromeSemantic proximity Read ↗

Sézary syndrome with elevated serum IgE and hypereosinophilia: role of dysregulated cytokine production.Semantic proximity Read ↗

Interleukin-7 is a growth factor of precursor B and T acute lymphoblastic leukemiaSemantic proximity Read ↗

The synergistic effects of interleukin 2 and interleukin 7 on the proliferation and autologous tumor cell lysis of tumor-associated lymphocytes.Semantic proximity Read ↗

Regulatory effects of interleukin-7 on renal tumor infiltrating lymphocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.