In vitro expression of thyroxine-binding globulin (TBG) variants. Impaired secretion of TBGPRO-227 but not TBGPRO-113.

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Article

In vitro expression of thyroxine-binding globulin (TBG) variants. Impaired secretion of TBGPRO-227 but not TBGPRO-113.

The Journal of biological chemistry - 15 Jul 1992

Janssen O E, Refetoff S

Abstract excerpt

Thyroxine-binding globulin (TBG) is a glycoprotein that transports thyroid hormones in blood. Of two naturally occurring variants in man that harbor single proline substitutions (TBG-CD5 and TBG-Montreal), only TBG-CD5 manifests as complete TBG deficiency. In order to determine the pathophysiolog...

Topics

Animals
Base Sequence
Cloning, Molecular
DNA
Escherichia coli
Genetic Variation
Genetic Vectors
Humans
Liver
Molecular Sequence Data
Mutagenesis, Site-Directed
Oligodeoxyribonucleotides
Oocytes
Polymerase Chain Reaction
Protein Biosynthesis
RNA
Recombinant Proteins
Restriction Mapping

Source

Open in PubMed

Identifiers

PMID: 1378434

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1378434-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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