Molecular basis of the thyroglobulin synthesis defect in Dutch goats.

doi:10.1210/endo.132.1.8380383

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Article

Molecular basis of the thyroglobulin synthesis defect in Dutch goats.

Endocrinology - 1 Jan 1993

Veenboer G J, de Vijlder J J

Abstract excerpt

A thyroglobulin (Tg) synthesis defect in Dutch goats causes congenital goiter and hypothyroidism. The disease is inherited in an autosomal recessive way and is linked to restriction fragment length polymorphisms (RFLPs) in the Tg gene. Previous studies showed that Tg mRNA isolated from the goiters was of normal size (8.4 kilobases). Translation of high mol wt polysomal Tg mRNA isolated from goiter in a cell-free...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
Codon
DNA
DNA Restriction Enzymes
Exons
Glycosylation
Goats
Goiter
Hypothyroidism
Molecular Sequence Data
Molecular Weight
Mutation
Polymerase Chain Reaction
RNA, Messenger
Thyroglobulin

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Open in PubMed

Identifiers

PMID: 8380383
DOI: 10.1210/endo.132.1.8380383

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