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Article

An additional carbohydrate chain in the variant thyroxine-binding globulin-Gary (TBGAsn-96) impairs its secretion.

Molecular endocrinology (Baltimore, Md.) - 1 Mar 1992

Kambe F, Seo H, Mori Y, Murata Y, Janssen O E, Refetoff S, Matsui N

Abstract excerpt

The T4-binding globulin-Gary (TBG-G) variant has severely impaired T4 binding, is unstable at 37 C, and presents an apparent anodal shift of all isoforms when submitted to isoelectric focusing. Inheritance of this abnormal TBG produces a profound decrease in the serum levels of native TBG with reciprocal changes in its denatured form, causing thyroid hormone concentrations to be as low as those found in complete...

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Identifiers

PMID: 1584218
DOI: 10.1210/mend.6.3.1584218

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