Article
An additional carbohydrate chain in the variant thyroxine-binding globulin-Gary (TBGAsn-96) impairs its secretion.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 1992
Kambe F, Seo H, Mori Y, Murata Y, Janssen O E, Refetoff S, Matsui N
Abstract excerpt
The T4-binding globulin-Gary (TBG-G) variant has severely impaired T4 binding, is unstable at 37 C, and presents an apparent anodal shift of all isoforms when submitted to isoelectric focusing. Inheritance of this abnormal TBG produces a profound decrease in the serum levels of native TBG with re...
Topics
- Animals
- Cells, Cultured
- Glycosylation
- Mutation
- Protein Processing, Post-Translational
- Thyroxine-Binding Proteins
- Xenopus laevis