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Article

Transgenic overexpression of BMP4 increases astroglial and decreases oligodendroglial lineage commitment.

Developmental biology - 1 Mar 2003

Gomes William A, Mehler Mark F, Kessler John A

Abstract excerpt

Bone morphogenetic proteins (BMPs) promote astrocytic differentiation of cultured subventricular zone stem cells. To determine whether BMPs regulate the astrocytic lineage in vivo, transgenic mice were constructed that overexpress BMP4 under control of the neuron-specific enolase (NSE) promoter. Overexpression of BMP4 was first detectable by Western analysis on embryonic day 16 and persisted into the adult. The...

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Source

Identifiers

PMID: 12618141
DOI: 10.1016/s0012-1606(02)00037-4

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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