Article
Phenotype changes resulting in high-affinity binding of von Willebrand factor to recombinant glycoprotein Ib-IX: analysis of the platelet-type von Willebrand disease mutations.
Blood - 15 Sept 2001
Tait A S, Cranmer S L, Jackson S P, Dawes I W, Chong B H
Abstract excerpt
To maintain hemostasis under shear conditions, there must be an interaction between the platelet glycoprotein (GP) Ib-IX receptor and the plasma ligand von Willebrand factor (vWf). In platelet-type von Willebrand disease (Pt-vWD), hemostasis is compromised. Two mutations in the GPIbalpha polypeptide chain have been identified in these patients-a glycine-233 to valine change and a methionine-239 to valine change....
Topics
- Animals
- CHO Cells
- Cell Adhesion
- Cell Aggregation
- Cricetinae
- Hemostasis
- Mutation
- Phenotype
- Platelet Glycoprotein GPIb-IX Complex
- Protein Binding
- Recombinant Proteins