Article
Persistent depletion of CD4+ T cells and inversion of the CD4/CD8 T cell ratio induced by anti-CD4 therapy.
The Journal of rheumatology - 1 Dec 1992
Horneff G, Emmrich F, Reiter C, Kalden J R, Burmester G R
Abstract excerpt
A 49-year-old patient with refractory rheumatoid arthritis was treated repeatedly with anti-CD4 murine monoclonal antibodies. While the first anti-CD4 treatment resulted in a marked, however transient, depletion of CD4+ cells from 1070 to a minimum of 175/microliters, a second treatment cycle resulted in a persistent decrease. Despite this marked depletion, no major clinical improvement occurred, which was in...
Topics
- Antibodies, Monoclonal
- Arthritis, Rheumatoid
- CD4 Antigens
- CD4-CD8 Ratio
- CD4-Positive T-Lymphocytes
- Chlorambucil
- Dose-Response Relationship, Drug
- Enzyme-Linked Immunosorbent Assay
- Humans
- Immunoblotting