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Article

High dose versus low dose fludarabine in the treatment of patients with severe refractory rheumatoid arthritis.

The Journal of rheumatology - 1 Sept 1998

Davis J C, Fessler B J, Tassiulas I O, McInnes I B, Yarboro C H, Pillemer S, Wilder R, Fleisher T A, Klippel J H, Boumpas D T

Abstract excerpt

OBJECTIVE: Fludarabine, a nucleoside analog that targets both resting and proliferating lymphocytes, is a promising drug for the treatment of autoimmune diseases. We conducted a 2 dose, open label clinical trial to evaluate the toxicity/safety of the fludarabine treatment and its clinical and imm...

Topics

Antigens, CD
Arthritis, Rheumatoid
Dose-Response Relationship, Drug
Female
Humans
Immunosuppressive Agents
Leukocytes, Mononuclear
Lymphocyte Count
Male
Middle Aged
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Platelet Count

Time Factors

Treatment Outcome

Vidarabine

Source

Identifiers

PMID: 9733448

Genes

ACR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9733448-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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