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Article

Purification and characterization of NF-R1 that regulates the expression of the human multidrug resistance (MDR1) gene.

Nucleic acids research - 11 Nov 1992

Ogura M, Takatori T, Tsuruo T

Abstract excerpt

We have purified a protein, NF-R1, that specifically binds to two unrelated motifs--the ATTCAGTCA motif and the GC-box motif--on the MDR1 proximal promoter. Purified NF-R1 has been confirmed by southwestern blotting to be a 110-kDa protein. Methylation interference analysis revealed that the nucleotides were in close contact with purified NF-R1 on the ATTCAGTCA and GC-box motifs. The nucleotides were required for...

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Identifiers

PMID: 1360648
DOI: 10.1093/nar/20.21.5811
PMCID: PMC334420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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