Article
The effect of donor T lymphocytes and total-body irradiation on hemopoietic engraftment and pulmonary toxicity following experimental allogeneic bone marrow transplantation.
Transplantation - 1 Nov 1992
Down J D, Mauch P, Warhol M, Neben S, Ferrara J L
Abstract excerpt
To study the effects of donor T lymphocytes on engraftment and graft-versus-host disease in relation to recipient total-body irradiation, we have returned small numbers of T cells to T-cell-depleted bone marrow transplanted across a minor histocompatibility barrier in mice (B10.BR-->CBA). T-cell-depleted B10.BR marrow (10(7) cells) was transplanted into CBA recipients prepared with TBI doses ranging from 4 to 14...
Topics
- Alleles
- Animals
- Bone Marrow Transplantation
- Carbonic Anhydrases
- Graft vs Host Disease
- Hematopoietic Stem Cell Transplantation
- Hematopoietic Stem Cells
- Hemoglobins
- Lung
- Lymphocyte Depletion