Article
Phenotypic characteristics of familial Creutzfeldt-Jakob disease associated with the codon 178Asn PRNP mutation.
Annals of neurology - 1 Mar 1992
Brown P, Goldfarb L G, Kovanen J, Haltia M, Cathala F, Sulima M, Gibbs C J, Gajdusek D C
Abstract excerpt
A group of 43 patients from seven families affected by Creutzfeldt-Jakob disease (CJD) with the codon 178Asn mutation of the PRNP amyloid precursor gene is compared to a group of 211 patients with the sporadic form of the disease. As a group, the patients with the codon 178Asn mutation had an earlier age at onset of illness (almost always presenting as an insidious loss of memory), a longer duration of illness,...
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