Article
Expression of c-erbB-2 in in situ and in adjacent invasive ductal adenocarcinomas of the female breast.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 1992
Maguire H C, Hellman M E, Greene M I, Yeh I
Abstract excerpt
Several lines of evidence have demonstrated that expression of the c-erbB-2 gene product contributes to the malignant phenotype. We and others have determined that c-erbB-2 is substantially expressed in most ductal in situ carcinomas of the comedo type, but not in other patterns of ductal carcinoma in situ or in atypical ductal hyperplasia of the breast. In the present investigation, by immunohistochemistry we...
Topics
- Breast Neoplasms
- Carcinoma in Situ
- Carcinoma, Intraductal, Noninfiltrating
- Female
- Fibrocystic Breast Disease
- Gene Expression Regulation, Neoplastic
- Humans
- Neoplasm Invasiveness
- Neoplasm Proteins
- Oncogenes