Article
C-myc oncogene amplification in ductal carcinoma in situ of the breast.
Breast cancer research and treatment - 1 Jul 2002
Aulmann Sebastian, Bentz Martin, Sinn Hans Peter
Abstract excerpt
The c-myc oncogene is frequently activated in invasive breast cancer and has been associated with high nuclear grade, lymph node metastasis and poorer disease outcome. We have examined c-myc oncogene amplification using fluorescence in situ hybridization in a series of 96 pure DCIS. Additionally we assessed amplification and expression of the Her2 and bcl-2 oncogenes. The findings were compared with...
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