C-myc oncogene amplification in ductal carcinoma in situ of the breast.

doi:10.1023/a:1016061327812

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Article

C-myc oncogene amplification in ductal carcinoma in situ of the breast.

Breast cancer research and treatment - 1 Jul 2002

Aulmann Sebastian, Bentz Martin, Sinn Hans Peter

Abstract excerpt

The c-myc oncogene is frequently activated in invasive breast cancer and has been associated with high nuclear grade, lymph node metastasis and poorer disease outcome. We have examined c-myc oncogene amplification using fluorescence in situ hybridization in a series of 96 pure DCIS. Additionally we assessed amplification and expression of the Her2 and bcl-2 oncogenes. The findings were compared with...

Topics

Adult
Aged
Breast Neoplasms
Carcinoma, Intraductal, Noninfiltrating
Cell Division
Disease Progression
Female
Gene Amplification
Genes, myc
Humans
Middle Aged
Neoplasm Staging
Phenotype

Source

Open in PubMed

Identifiers

PMID: 12150449
DOI: 10.1023/a:1016061327812

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