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Article

ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization.

15 Jun 1992

Abstract excerpt

We illustrate the use of fluorescence in situ hybridization (FISH) for analysis of ERBB2 oncogene copy number, the level of amplification (here defined as the ratio of ERBB2 copy number to copy number of chromosome 17 centromeres), and the distribution of amplified genes in breast cancer cell lines and uncultured primary breast carcinomas. The relative ERBB2 copy number determined by FISH in 10 breast cancer cell...

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PMID: 1351679
DOI: 10.1073/pnas.89.12.5321

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