Article
Loss of normal allele of the APC gene in an adrenocortical carcinoma from a patient with familial adenomatous polyposis.
Human genetics - 1 May 1992
Seki M, Tanaka K, Kikuchi-Yanoshita R, Konishi M, Fukunari H, Iwama T, Miyaki M
Abstract excerpt
Endocrine neoplasms have been reported occasionally in patients with familial adenomatous polyposis (FAP). An adrenocorotical carcinoma was studied in a patient with a family history of FAP. Loss of heterozygosity (LOH) in the region close to the adenomatous polyposis coli (APC) gene was detected...
Topics
- Adenomatous Polyposis Coli
- Adrenal Cortex Neoplasms
- Alleles
- Blotting, Southern
- Carcinoma
- Chromosomes, Human, Pair 5
- Female
- Homozygote
- Humans
- Male
- Middle Aged
- Neoplasms, Multiple Primary
- Polymorphism, Restriction Fragment Length