Article
[Molecular genetic studies in alpha-thalassemia].
Nederlands tijdschrift voor geneeskunde - 2 May 1992
de Korte D, Cuypers H T, de Klein A, Winkel I, Vuil H, Roos D
Abstract excerpt
A group of 5,000 patients, suspected of haemolytic anaemia, were investigated with molecular genetic methods for deletion types of alpha-thalassemia. In 776 (15.6%) patients a deletion of one or more alpha-globin genes was found. The same group of patients was also investigated for abnormal haemoglobins and beta-thalassaemia. In about 30% of the patients either an alpha-thalassaemia, an abnormal haemoglobin, a...
Topics
- Chromosome Deletion
- Chromosomes, Human, Pair 16
- DNA
- Erythrocyte Indices
- Genotype
- Globins
- Humans
- Polymorphism, Restriction Fragment Length
- Thalassemia