Article
Construction and analysis of Bordetella pertussis mutants defective in the production of fimbriae.
Microbial pathogenesis - 1 Feb 1992
Mooi F R, Jansen W H, Brunings H, Gielen H, van der Heide H G, Walvoort H C, Guinee P A
Abstract excerpt
Although the role of fimbriae in bacterial disease has been well established, little is known about the function of Bordetella pertussis fimbriae. To study this function, well-defined fimbrial mutants were constructed. B. pertussis harbours three fimbrial genes, fim2, fim3 and fimX, and strains were constructed in which one or more fimbrial genes were inactivated by means of gene replacement. Analysis of these...
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