Article
Role of (p)ppGpp in biofilm formation and expression of filamentous structures in Bordetella pertussis.
Microbiology (Reading, England) - 1 Jul 2013
Sugisaki Kentaro, Hanawa Tomoko, Yonezawa Hideo, Osaki Takako, Fukutomi Toshiyuki, Kawakami Hayato, Yamamoto Tomoko, Kamiya Shigeru
Abstract excerpt
Bordetella pertussis, the causative agent of whooping cough, is highly adapted to cause human infection. The production of virulence factors, such as adhesins and toxins, is just part of an array of mechanisms by which B. pertussis causes infection. The stringent response is a global bacterial response to nutritional limitation that is mediated by the accumulation of cellular ppGpp and pppGpp [termed together as...
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