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Article

Efficiency and accuracy of polymerase-chain-reaction assay for cystic fibrosis allele delta F508 in single cell.

Lancet (London, England) - 16 May 1992

Liu J, Lissens W, Devroey P, Van Steirteghem A, Liebaers I

Abstract excerpt

Diagnosis of genetic disorders in the embryo before implantation, though possible by removal of one or two blastomeres at the eight-cell stage, is still experimental because the procedures of gene analysis of DNA from a single cell are not yet reliable enough for clinical application. We have evaluated the efficiency and accuracy of polymerase-chain-reaction (PCR) amplification of a single-copy gene, wild-type or...

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Identifiers

PMID: 1349937
DOI: 10.1016/0140-6736(92)91133-s

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Efficiency and accuracy of polymerase-chain-reaction assay for cystic fibrosis allele delta F508 in single cell.PMID 1349937Read ↗

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Direct comparison of detection systems used for the development of single-cell genetic tests in preimplantation genetic diagnosis.Semantic proximity Read ↗

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