Article
[Affected siblings with Alzheimer's disease had missense mutation of codon 717 in amyloid precursor protein gene].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics - 1 Feb 1992
Katsuya T, Miki T, Tanabe H, Takeda M, Hosokawa K, Hayashi H, Hashimoto S, Nishimura T, Ogihara T
Abstract excerpt
Using reverse genetic techniques, the gene responsible for familial Alzheimer's disease (FAD) is one of the clues to identify the pathogenesis of Alzheimer's disease (AD). Recently a missense mutation in the APP (amyloid precursor protein) gene (generally this mutation was called APP717) was dete...
Topics
- Alzheimer Disease
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Codon
- Family Health
- Genes
- Humans
- Male
- Middle Aged
- Mutation
- Protein Precursors