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[Early-onset Alzheimer's disease with PSEN1 G206D mutation presenting with amnesia at an onset age of 29 years old].

Rinsho shinkeigaku = Clinical neurology - 26 May 2026

Funakawa Kai, Kurihara Masanori, Takahashi Kensuke, Ihara Ryoko, Kakumoto Toshiyuki, Ishibashi Kenji, Ishii Kenji, Fujii Yuki, Kobayashi Shunsuke, Iwata Atsushi

Abstract excerpt

The patient was a 36-year-old woman with normal birth and development. The patient experienced gradual memory loss from the age of 29 years old. The patient showed irritability at 35, convulsion at 36, and was diagnosed to have early-onset dementia. Family history of early-onset dementia was suspected in her mother and her brother. Brain MRI showed atrophy mainly in parietal lobe and posterior cingulate cortes....

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Identifiers

PMID: 41967920
DOI: 10.5692/clinicalneurol.cn-002216

Genes

PSEN1

Variants

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[Early-onset Alzheimer's disease with PSEN1 G206D mutation presenting with amnesia at an onset age of 29 years old].PMID 41967920Read ↗

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