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Article

A genetic study of idiopathic torsion dystonia in the United Kingdom.

Brain : a journal of neurology - 1 Apr 1990

Fletcher N A, Harding A E, Marsden C D

Abstract excerpt

The inheritance of idiopathic torsion dystonia (ITD) was investigated in 100 British families containing 107 index cases with generalized, multifocal or segmental dystonia, and 79 secondary cases. Fifty-eight index cases had affected relatives, usually in two or more generations. Nearly half of the secondary cases were asymptomatic. Paternal age was increased among the 49 single cases, parental consanguinity was...

Topics

Adolescent
Adult
Aged
Child
Child, Preschool
Dystonia
Female
Genetic Techniques
Genetic Variation
Humans
Male
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Paternal Age

Pedigree

Physical Fitness

United Kingdom

Source

Identifiers

PMID: 2183913
DOI: 10.1093/brain/113.2.379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2183913-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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