Article
Cloning and transcriptional regulation of a novel adipocyte-specific gene, FSP27. CAAT-enhancer-binding protein (C/EBP) and C/EBP-like proteins interact with sequences required for differentiation-dependent expression.
The Journal of biological chemistry - 5 Apr 1992
Danesch U, Hoeck W, Ringold G M
Abstract excerpt
We have reported previously the cloning of several cDNAs whose mRNAs are induced during differentiation of the adipogenic cell line TA1. Here we characterize an adipocyte-specific gene, which we refer to as FSP27 (formerly clone 47), that encodes a protein of 27 kDa, the sequence of which is unrelated to any in the current data banks. The FSP27 promoter confers adipocyte-specific expression to a heterologous...
Topics
- Adipose Tissue
- Amino Acid Sequence
- Base Sequence
- Blotting, Northern
- CCAAT-Enhancer-Binding Proteins
- Cell Differentiation
- Cells, Cultured
- Chloramphenicol O-Acetyltransferase
- Cloning, Molecular
- DNA