Article
Large granular lymphocytosis terminating in a polymorphous B-lymphocytic proliferation after low-dose cyclophosphamide therapy: a case report with necropsy findings.
Hematologic pathology - 1 Jan 1992
Friedman H D, Kurec A S, Goldberg J, Coyle T E, Poiesz B J
Abstract excerpt
A 70-year-old man presented with clonal large granular lymphocytosis of T-suppressor/cytotoxic immunophenotype, neutropenia, paraproteinemia, and proneness to infection. The patient became severely leukopenic during 14 days of chemotherapy with low-dose cyclophosphamide, and remained so after dis...
Topics
- Aged
- Autopsy
- B-Lymphocytes
- Cell Division
- Cyclophosphamide
- Gene Rearrangement, B-Lymphocyte
- Gene Rearrangement, T-Lymphocyte
- Genotype
- Herpesvirus 4, Human
- Humans
- Leukocytes, Mononuclear
- Lymphocytosis
- Lymphoproliferative Disorders
- Male
- Retroviridae Infections