Article
T-gamma delta large granular lymphocyte leukemia preceded by pure red cell aplasia and complicated with hemophagocytic syndrome caused by Epstein-Barr virus infection.
Internal medicine (Tokyo, Japan) - 1 Jan 2006
Tanaka Yoshinori, Matsui Kumiko, Yamashita Koji, Matsuda Kazuhiro, Shinohara Kenji, Matsutani Akira
Abstract excerpt
A 51-year-old man developed anemia, and was diagnosed with pure red cell aplasia through the absence of erythroid progenitors. Initially, he was treated with cyclosporine and prednisolone for 6 months but they were ineffective. Large granular lymphocyte (LGL) leukemia with the T-cell gamma delta phenotype evolved after 6 months showing CD2+, CD3+, CD8- and CD56- with the T-cell receptor beta gene rearrangement,...
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