Article
Evidence that intergenic spacer repeats of Drosophila melanogaster rRNA genes function as X-Y pairing sites in male meiosis, and a general model for achiasmatic pairing.
Genetics - 1 Oct 1992
McKee B D, Habera L, Vrana J A
Abstract excerpt
In Drosophila melanogaster males, X-Y meiotic chromosome pairing is mediated by the nucleolus organizers (NOs) which are located in the X heterochromatin (Xh) and near the Y centromere. Deficiencies for Xh disrupt X-Y meiotic pairing and cause high frequencies of X-Y nondisjunction. Insertion of cloned rRNA genes on an Xh- chromosome partially restores normal X-Y pairing and disjunction. To map the sequences...
Topics
- Animals
- Base Sequence
- Cell Nucleolus
- DNA Transposable Elements
- DNA, Ribosomal
- Drosophila melanogaster
- Gene Deletion
- Introns
- Male
- Meiosis
- Models, Genetic