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Article

A circadian clock of Drosophila: effects of deuterium oxide and mutations at the period locus.

Chronobiology international - 1 Aug 1992

White L, Ringo J, Dowse H

Abstract excerpt

Mutations at the period (per) locus (1:1.3; 3B1-2) in Drosophila melanogaster lengthen (perL), shorten (pers), or abolish (per0) overt circadian rhythmicity. Deuterium oxide lengthens the free-running circadian period. We tested the effects of deuterium on three mutants of the per gene (pers, perL, and per0) and wild-type Drosophila melanogaster (per+) to assess interactions. With increasing concentrations of...

Topics

Analysis of Variance
Animals
Circadian Rhythm
Deuterium
Deuterium Oxide
Drosophila melanogaster
Genotype
Mutation
Water

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1330336
DOI: 10.3109/07420529209064534

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1330336-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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