Article
Effect of deuterium on the circadian period and metabolism in wild-type and tau mutant Syrian hamsters.
Physiology & behavior - 1 Jan 2000
Oklejewicz M, Hut R A, Daan S
Abstract excerpt
Homozygous tau mutant Syrian hamsters (tau-/-) have a free-running circadian period (tau) around 20 h and a proportionally higher metabolic rate compared with wild-type hamsters (tau+/+) with a period of circa 24 h. In this study, we applied deuterium oxide (D(2)O) to hamsters to test whether deuteration affects the circadian period of locomotor activity and metabolic rate in both genotypes. Running wheel...
Topics
- Animals
- Basal Metabolism
- Circadian Rhythm
- Cricetinae
- Deuterium
- Genotype
- Male
- Mesocricetus
- Motor Activity
- Mutation
- tau Proteins
