Article
Two major types of JC virus defined in progressive multifocal leukoencephalopathy brain by early and late coding region DNA sequences.
The Journal of general virology - 1 Oct 1992
Ault G S, Stoner G L
Abstract excerpt
A 610-bp region of the JC virus (JCV) genome sequenced from brains of 11 progressive multifocal leukoencephalopathy (PML) patients contains 20 sites of point mutations that allow reliable classification of JCV isolates into two types. These type-determining sites were located in the region extend...
Topics
- Antigens, Polyomavirus Transforming
- Base Sequence
- Biological Evolution
- Capsid
- Capsid Proteins
- DNA Restriction Enzymes
- DNA, Viral
- Genes, Viral
- Genetic Variation
- Humans
- JC Virus
- Leukoencephalopathy, Progressive Multifocal
- Molecular Sequence Data
- Sequence Analysis, DNA
- Substrate Specificity
- Transcription, Genetic