Article
Two active copies of the X-linked gene spermidine/spermine N1-acetyltransferase (SSAT) in a female lung cancer cell line are associated with an increase in sensitivity to an antitumor polyamine analogue.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 1998
Mank-Seymour A R, Murray T R, Berkey K A, Xiao L, Kern S, Casero R A
Abstract excerpt
The expression of the polyamine catabolic enzyme, spermidine/spermine N1-acetyltransferase (SSAT), has been associated with tumor sensitivity to antitumor polyamine analogues. In the sensitive cell types the level of SSAT is greatly induced by these agents. Although SSAT expression is regulated a...
Topics
- Acetyltransferases
- Alleles
- Antineoplastic Agents
- Biogenic Polyamines
- Cell Division
- Cell Survival
- DNA Methylation
- DNA, Neoplasm
- Enzyme Induction
- Female
- Genetic Linkage
- Humans
- Lung Neoplasms
- Male