Mapping of homologous, amino-terminal neutralizing regions of human T-cell lymphotropic virus type I and II gp46 envelope glycoproteins.

doi:10.1128/JVI.66.10.5879-5889.1992

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Article

Mapping of homologous, amino-terminal neutralizing regions of human T-cell lymphotropic virus type I and II gp46 envelope glycoproteins.

Journal of virology - 1 Oct 1992

Palker T J, Riggs E R, Spragion D E, Muir A J, Scearce R M, Randall R R, McAdams M W, McKnight A, Clapham P R, Weiss R A

Abstract excerpt

Twelve synthetic peptides containing hydrophilic amino acid sequences of human T-cell lymphotropic virus type I (HTLV-I) envelope glycoprotein were coupled to tetanus toxoid and used to raise epitope-specific antisera in goats and rabbits. Low neutralizing antibody titers (1:10 to 1:20) raised in rabbits to peptides SP-2 (envelope amino acids [aa] 86 to 107), SP-3 (aa 176 to 189), and SP-4A (aa 190 to 209) as...

Topics

Amino Acid Sequence
Animals
Blotting, Western
Gene Products, env
Goats
HTLV-I Antibodies
HTLV-II Antibodies
Immune Sera
Immunohistochemistry
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neutralization Tests

Peptides

Rabbits

Radioimmunoassay

Retroviridae Proteins, Oncogenic

Vesicular stomatitis Indiana virus

env Gene Products, Human Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 1326649
DOI: 10.1128/JVI.66.10.5879-5889.1992
PMCID: PMC241464

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1326649-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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