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Article

Retinoic acid receptors initiate induction of the cytomegalovirus enhancer in embryonal cells.

15 Aug 1992

Abstract excerpt

Reactivation of latent virus is believed to result from a signal transduction event that induces immediate-early (IE) gene transcription. Evidence is presented that the major IE promoter (MIEP) of human cytomegalovirus (hCMV) is activated by physiological levels of retinoic acid (RA) in human embryonal carcinoma cells. Mutagenesis experiments localized in the MIEP enhancer, a retinoic acid-responsive element...

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Identifiers

PMID: 1323848
DOI: 10.1073/pnas.89.16.7630

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