[Genetic analysis of adenomatous polyposis coli: analysis of alterations of oncogenes and tumor suppressor genes in colorectal tumors].

Abstract excerpt

Adenomatous polyposis coli (APC) is a genetic disorder transmitted as an autosomal dominant trait. This syndrome is characterized by the development of numerous polyps during the first 20-30 years of life and classified into two phenotypes according to the number of polyps: the profuse and sparse types. If left untreated, most or all affected individuals are at a high risk of developing adenocarcinoma by as early...

Topics

• Adenomatous Polyposis Coli
• Alleles
• Animals
• Base Sequence
• Chromosomes, Human, Pair 18
• Chromosomes, Human, Pair 5
• Gene Amplification
• Genes, DCC
• Genes, p53
• Genes, ras
• Heterozygote