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Article

Lymphocyte subsets associated with T cell receptor beta-chain gene rearrangement in patients with rheumatoid arthritis and neutropenia.

Arthritis and rheumatism - 1 May 1992

Gonzales-Chambers R, Przepiorka D, Winkelstein A, Agarwal A, Starz T W, Kline W E, Hawk H

Abstract excerpt

OBJECTIVE: To determine the incidence of a clonal lymphoid disease in patients with chronic rheumatoid arthritis (RA) and neutropenia. METHODS: Lymphocytes from 23 RA patients with either current neutropenia or a history of this complication were studied. RESULTS: Eight patients had a clonal rearrangement of the T cell receptor beta-chain gene. Phenotypically, they showed a distinctive pattern characterized by an...

Topics

Adult
Arthritis, Rheumatoid
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Humans
Lymphocyte Subsets
Neutropenia
Organ Size
Phenotype
Receptors, Antigen, T-Cell, alpha-beta
Spleen

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Identifiers

PMID: 1315549
DOI: 10.1002/art.1780350505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1315549-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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