Article
Pseudorabies virus envelope glycoprotein gI influences both neurotropism and virulence during infection of the rat visual system.
Journal of virology - 1 May 1992
Card J P, Whealy M E, Robbins A K, Enquist L W
Abstract excerpt
We previously demonstrated that intraocular injections of virulent and attenuated strains of pseudorabies virus (PRV) produce transneuronal infection of functionally distinct central visual circuits in the rat. The virulent Becker strain of PRV induces two temporally separated waves of infection that ultimately target all known retinorecipient neurons; the attenuated Bartha strain only infects a functionally...
Topics
- Animals
- Central Nervous System Diseases
- DNA Mutational Analysis
- Genome, Viral
- Herpesvirus 1, Suid
- Host-Parasite Interactions
- Male
- Mutagenesis
- Phenotype
- Prosencephalon
- Retina