Deficient nifedipine oxidation: a rare inherited trait associated with cystic fibrosis kindreds.

doi:10.1097/00008571-199202000-00004

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Article

Deficient nifedipine oxidation: a rare inherited trait associated with cystic fibrosis kindreds.

Pharmacogenetics - 1 Feb 1992

Daly A K, Salh B S, Bilton D, Allen J, Knight A D, Webb A K, Braganza J M, Idle J R

Abstract excerpt

Previous studies have indicated that there is weak genetic linkage between the defective gene in cystic fibrosis (CFTR) and the gene encoding the nifedipine metabolizing enzyme P4503A4 which are both located on chromosome 7. To examine further this possible association, nifedipine metabolism was investigated in a group of 59 volunteers, and 17 adult cystic fibrosis patients and 37 of their relatives. In agreement...

Topics

Adolescent
Adult
Aryl Hydrocarbon Hydroxylases
Base Sequence
Cystic Fibrosis
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System
DNA
Female
Genetic Linkage
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Molecular Sequence Data

Nifedipine

Oxidation-Reduction

Oxidoreductases, N-Demethylating

Pedigree

Phenotype

Source

Open in PubMed

Identifiers

PMID: 1302038
DOI: 10.1097/00008571-199202000-00004

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1302038-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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