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Finding Homes for Orphan Cytochrome P450s: CYP4V2 and CYP4F22 in Disease States

1 Apr 2011

Abstract excerpt

The cytochrome P450 (CYP) 4 family of enzymes contains several recently identified membersthat are referred to as “orphan P450s” because their endogenous substrates are unknown.Human CYP4V2 and CYP4F22 are two such orphan P450s that are strongly linked to ocular andskin disease, respectively. Genetic analyses have identified a wide spectrum of mutations in the CYP4V2gene from patients suffering from Bietti’s...

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PMID: 21540472
DOI: 10.1124/mi.11.2.10

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