Article
Thalassemic serum impairs endothelial cell growth in vitro.
The Southeast Asian journal of tropical medicine and public health - 1 Jan 1992
Bunyaratvej A, Funahara Y, Butthep P, Kitaguchi H, Fucharoen S
Abstract excerpt
Endothelial cells cultured for 3 days in the presence of hemoglobin H pooled sera had significantly decreased cell proliferation compared to those in normal serum. Inhibition was demonstrated at a concentration of 20% pooled serum in the cultured medium. Further decrease was shown in the presence of 30% pooled hemoglobin H sera. Sera from two genotypes of Hb H disease (alpha-thal 1/alpha-thal 2 and alpha-thal...
Topics
- Bilirubin
- Cell Division
- Cells, Cultured
- Culture Media
- Endothelium, Vascular
- Genotype
- Hemoglobinopathies
- Hemoglobins, Abnormal
- Humans
- Infant, Newborn
- Splenectomy