Article
Identification of genes modulated in multiple myeloma using genetically identical twin samples.
Blood - 1 Mar 2004
Munshi Nikhil C, Hideshima Teru, Carrasco Daniel, Shammas Masood, Auclair Daniel, Davies Faith, Mitsiades Nicholas, Mitsiades Constantine, Kim Ryung Suk, Li Cheng, Rajkumar S Vincent, Fonseca Rafael, Bergsagel Lief, Chauhan Dharminder, Anderson Kenneth C
Abstract excerpt
Genetic heterogeneity between individuals confounds the comparison of gene profiling of multiple myeloma (MM) cells versus normal plasma cells (PCs). To overcome this barrier, we compared the gene expression profile of CD138+ MM cells from a patient bone marrow (BM) sample with CD138+ PCs from a genetically identical twin BM sample using microarray profiling. Two hundred and ninety-six genes were up-regulated and...
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