Article
The role of apoptosis in the pathophysiology of chronic neutropenias associated with bone marrow failure.
Cell cycle (Georgetown, Tex.) - 1 Jan 2000
Papadaki Helen A, Eliopoulos George D
Abstract excerpt
Chronic neutropenia syndromes associated with bone marrow (BM) failure comprise distinct congenital and acquired hematologic disorders with varying degree of neutropenia due to decreased or ineffective BM neutrophil production. Recent evidence suggests that defective granulocytopoiesis in these neutropenia states is a consequence of accelerated apoptotic cell death of BM myeloid progenitor cells and/or their...
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