Article
Status of the NF1 tumor suppressor locus in uveal melanoma.
Archives of ophthalmology (Chicago, Ill. : 1960) - 1 Sept 2003
Foster William J, Fuller Christine E, Perry Arie, Harbour J William
Abstract excerpt
BACKGROUND: A clinical association has been observed between uveal melanoma and neurofibromatosis type 1 (NF1). This study aims to determine whether the NF1 tumor suppressor gene is mutated in uveal melanoma. METHODS: Thirty-eight uveal melanomas, as well as normal uveal melanocytes, were examined for NF1 deletions by dual-color fluorescence in situ hybridization, and for expression of the NF1 protein...
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