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Differential effects of invasion by and phagocytosis of <i>Salmonella typhimurium</i> on apoptosis in human macrophages: potential role of Rho–GTPases and Akt

15 Jul 2003

Abstract excerpt

In addition to direct activation of caspase-1 and induction of apoptosis by SipB, invasive Salmonella stimulates multiple signaling pathways that are key regulators of host cell survival. Nevertheless, little is known about the relative contributions of these pathways to Salmonella-mediated death of macrophages. We studied human monocytic U937 cells and found that apoptosis was induced by invading wild-type...

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PMID: 12960245
DOI: 10.1189/jlb.1202586

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