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<i>Salmonella</i> Pathogenesis and Processing of Secreted Effectors by Caspase-3

14 Oct 2010

Abstract excerpt

The enteric pathogen Salmonella enterica serovar Typhimurium causes food poisoning resulting in gastroenteritis. The S. Typhimurium effector Salmonella invasion protein A (SipA) promotes gastroenteritis by functional motifs that trigger either mechanisms of inflammation or bacterial entry. During infection of intestinal epithelial cells, SipA was found to be responsible for the early activation of caspase-3, an...

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PMID: 20947770
DOI: 10.1126/science.1194598

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