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Article

The DJ-1L166P mutant protein associated with early onset Parkinson's disease is unstable and forms higher-order protein complexes.

Human molecular genetics - 1 Nov 2003

Macedo Maria G, Anar Burcu, Bronner Iraad F, Cannella Milena, Squitieri Ferdinando, Bonifati Vincenzo, Hoogeveen André, Heutink Peter, Rizzu Patrizia

Abstract excerpt

Parkinson's disease (PD) is a common neurodegenerative disorder that involves the selective degeneration of midbrain dopaminergic neurons. Recently DJ-1 mutations have been linked to autosomal-recessive early-onset Parkinsonism in two European families. By using gel filtration assays under physiological conditions we demonstrate that DJ-1 protein forms a dimeric structure. Conversely, the DJ-1L166P mutant protein...

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PMID: 12952867
DOI: 10.1093/hmg/ddg304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The DJ-1L166P mutant protein associated with early onset Parkinson's disease is unstable and forms higher-order protein complexes.PMID 12952867Read ↗

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L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system.Semantic proximity Read ↗

BAG1 restores formation of functional DJ-1 L166P dimers and DJ-1 chaperone activitySemantic proximity Read ↗

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The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease.Semantic proximity Read ↗

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