Article
HLA-DQ polymorphisms modify the risk of thyroid autoimmunity in children with type 1 diabetes mellitus.
Journal of pediatric endocrinology & metabolism : JPEM - 1 Jan 2000
Sumník Z, Drevínek P, Snajderová M, Kolousková S, Sedláková P, Pechová M, Vavrinec J, Cinek O
Abstract excerpt
OBJECTIVE: Type 1 diabetes mellitus (DM1) is frequently accompanied by thyroid autoimmunity (TAI). The aims of the present study were to estimate the prevalence of TAI and to determine the contribution of HLA-DQA1 and -DQB1 polymorphisms to TAI susceptibility among children with DM1. PATIENTS AND METLHODS: Screening for TAI was performed in 285 children with DM1 by measuring autoantibodies against thyroid...
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