Article
Inhibitor kappa B-alpha (IkappaB-alpha) promoter polymorphisms in UK and Dutch sarcoidosis.
Genes and immunity - 1 Sept 2003
Abdallah A, Sato H, Grutters J C, Veeraraghavan S, Lympany P A, Ruven H J T, van den Bosch J M M, Wells A U, du Bois R M, Welsh K I
Abstract excerpt
The aetiology of sarcoidosis is uncertain; current thinking implicates exposure of genetically susceptible hosts to environmental factors. The nuclear factor kappa B (NF-kappaB) family of transcription factors are critical regulators of immediate transcriptional responses in inflammatory situatio...
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