Ntg1 and Ntg2 proteins as 5-formyluracil-DNA glycosylases/AP lyases in Saccharomyces cerevisiae.

doi:10.1080/0955300032000093119

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Article

Ntg1 and Ntg2 proteins as 5-formyluracil-DNA glycosylases/AP lyases in Saccharomyces cerevisiae.

International journal of radiation biology - 1 May 2003

Zhang Q M, Hashiguchi K, Kino K, Sugiyama H, Yonei S

Abstract excerpt

PURPOSE: 5-Formyluracil (5-foU) is a potentially mutagenic lesion of thymine produced in DNA by ionizing radiation and various chemical oxidants. The present authors reported previously that MutM, Nth and Nei in Escherichia coli removed 5-foU from DNA. The present study identified 5-foU DNA glycosylases in Saccharomyces cerevisiae in order to clarify the repair mechanisms of 5-foU in eukaryotic cells. MATERIALS...

Topics

Base Sequence
Carbon-Oxygen Lyases
DNA Repair
DNA, Fungal
DNA-(Apurinic or Apyrimidinic Site) Lyase
Genes, Fungal
Mutation
N-Glycosyl Hydrolases
Reactive Oxygen Species
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Uracil

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Identifiers

PMID: 12943242
DOI: 10.1080/0955300032000093119

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