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Article

A single amino acid deletion in the antigen binding site of BoLA-DRB3 is predicted to affect peptide binding.

Veterinary immunology and immunopathology - 1 Mar 2002

Sitte Karin, Brinkworth Ross, East Iain J, Jazwinska Elizabeth C

Abstract excerpt

Two bovine MHC class II alleles, BoLA-DRB3*0201 and BoLA-DRB3*3301, contain a three base pair deletion which results in the deletion of a lysine (K beta 65) in the antigen recognition site (ARS). Modelling of BoLA-DRB3*0201 with the conserved lysine K beta 65 and BoLA-DRB3*0201 without K beta 65 indicated that this deletion altered the peptide specificity of the ARS, and may impact on the immune response. To test...

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PMID: 11943314
DOI: 10.1016/s0165-2427(01)00430-5

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