Article
BoLA-DR peptide binding pockets are fundamental for foot-and-mouth disease virus vaccine design in cattle.
Vaccine - 10 Dec 2009
Baxter R, Craigmile S C, Haley C, Douglas A J, Williams J L, Glass E J
Abstract excerpt
This large study investigates the associations between bovine major histocompatibility complex DRB3 alleles and their binding pockets with the immune response to a 40-mer peptide derived from foot-and-mouth disease virus (FMDV) VP1. A crossbred (Charolais and Holstein) cattle population (n=197) was immunised with the FMDV peptide and specific IgG1 and IgG2 responses were measured. Eighteen different DRB3 alleles...
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